The Signal Study: A 12-week women's health research study
A placebo-controlled clinical trial evaluating a botanical blend for menopause symptom relief. No lab visits. No travel. Everything from home. Open to women ages 35 to 65 across the United States.
What participating looks like
This study is a 12-week, randomized, placebo-controlled trial. Some participants receive the active botanical blend and some receive a placebo. All participants receive the same experience and completion gift regardless of assignment.
Seven surveys over twelve weeks. That is it.
There are no lab visits, no travel, and no clinic appointments. Once you are enrolled, your study supplement is shipped to your door. You take it once daily and complete brief symptom surveys at scheduled intervals. Each survey takes approximately 10 to 15 minutes.
Complete your first survey before starting the supplement. Takes 10 to 15 minutes. Establishes your starting point across five symptom domains.
Brief check-in survey. How are you feeling one week in? Takes 10 minutes.
Second check-in survey. Same questions, tracking your trajectory. Takes 10 minutes.
Third check-in. The early timepoints are the most important in this study. Your responses here matter.
One month in. Survey captures your experience at the one-month mark across all five symptom domains.
Two-month check-in. Longer interval between surveys from here. Takes 10 to 15 minutes.
Final survey. Your 12-week endpoint data. Completion triggers your compensation and gift package.
Your responses are the data. There is no blood draw, no physical exam, no clinic visit. You are contributing something no lab test can capture: what this actually feels like from the inside.
Is this study a good fit for you?
Please review the criteria below before joining. If you are not sure, go ahead and submit and we will let you know.
You may be a good fit if you
You may not qualify if you
Full fit criteria are reviewed during screening. If you are uncertain about any item, submit and we will review your situation individually.
Compensation and completion gift
All participants receive the same compensation and completion package regardless of which study group they are assigned to.
Upon completing all seven surveys
- Access to a participants-only reveal virtual party where you learn which group you were in and what we found
- A copy of The Female Stress Protocol by Dr. Jessie Cavanaugh
- A curated NRI wellness gift, including a botanical preparation handcrafted by the Principal Investigator
- A personalized 12-week data summary report showing your individual symptom scores across all five domains at each timepoint, with plain-language interpretation of your trajectory
- Participants in the placebo arm receive a complimentary supply of the active study supplement from the sponsor after unblinding
The data summary report is something most research studies do not provide. You will see your own scores across vasomotor, psychosocial, physical, sexual, and cognitive domains at every assessment point, interpreted in plain language. That is your data. You earned it.
A study designed for how women actually experience menopause
This study is led by Dr. Jessie Cavanaugh, PhD, founder and Principal Investigator of Nutraceuticals Research Institute. Dr. Cavanaugh completed post-doctoral training at Harvard Medical School and has published over 30 peer-reviewed studies in women's health, stress physiology, and botanical medicine.
This study captures the full picture of how perimenopause affects daily life.
The study is IRB-approved and conducted in full compliance with federal research regulations. Your participation is voluntary, your data is kept confidential, and you may withdraw at any time without penalty.
Questions about the study
The study product is a once-daily botanical blend. Because this is a blinded study, we do not share the specific ingredients until after the study concludes and unblinding occurs. Full ingredient information is provided at the end of the study.
You will not know during the study, and neither will the research staff. This is called double-blinding. It is what makes the results scientifically valid. Both the active product and the placebo look and taste identical. At the end of the study, all participants are unblinded and told which group they were in.
No. The Signal Study is fully remote. You can participate from anywhere in the United States. The supplement is shipped to your home and all surveys are completed online.
Each survey takes approximately 10 to 15 minutes. They include validated symptom scales used in clinical research. The questions ask about your symptoms, wellbeing, and daily functioning across five domains.
You may withdraw from the study at any time for any reason without penalty. Compensation is provided at study completion. If you withdraw early, you are not compensated, but you are under no obligation to continue and there is no negative consequence for withdrawing.
Every participant is assigned a research team contact who is available throughout the study. You will receive direct contact information at enrollment. Questions are answered by a real person, not an automated system.
Ready to join the study?
We review every submission to make sure the study is a good fit, and will be in touch within five business days.
This study is IRB-approved and conducted in compliance with federal research regulations. Your information is kept confidential.
Not sure if this is right for you? Go ahead and submit. We review every submission individually and will let you know honestly whether this study is a good fit right now.
Questions before joining?
Reach out to the study team. We are happy to answer questions before you decide whether to apply.